Article ID Journal Published Year Pages File Type
8361302 Regulatory Peptides 2012 8 Pages PDF
Abstract
► Semapimod decreased lung and liver metastases in control animals but not in vagotomized animals. ► Semapimod increased substance P (SP) levels in capsaicin sensitive nerve endings. ► The effects of semapimod on SP levels were prevented by vagotomy. ► Semapimod increased neprilysin-like activity in lung tissue of control animals.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Activation of vagus nerve by semapimod alters substance P levels and decreases breast cancer metastasis
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