Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8361344 | Regulatory Peptides | 2012 | 8 Pages |
Abstract
⺠Chronic 2K1C rats showed hypertension and signs of cardiac failure. ⺠Apelin reduced BP and increased cardiac contractility indices in chronic 2K1C rats. ⺠Serum apelin reduced and aldosterone increased in chronic 2K1C hypertension. ⺠Apelin in medium and high doses induced opposite myocardial inotropic effects. ⺠Chronic 2K1C decreased apelin receptor mRNA and protein expression in both kidneys.
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Authors
Hamid Najafipour, Ava Soltani Hekmat, Ali Akbar Nekooian, Saeed Esmaeili-Mahani,