Article ID Journal Published Year Pages File Type
8361367 Regulatory Peptides 2012 9 Pages PDF
Abstract
► We examine the physiologic role of BDNF synergistic with SP/CGRP on mouse gut motility. ► We clarify the excitatory effects of SP and bilateral effects of CGRP on the contraction of LM strips. ► Pretreatment with exogenous BDNF enhances the contraction of LM strips induced by SP and CGRP. ► Reduction of endogenous BDNF attenuated the contraction of LM strips induced by SP and CGRP. ► BDNF accelerates gut motility by enhancing the excitatory effects of SP/CGRP.
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