| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8361370 | Regulatory Peptides | 2012 | 7 Pages |
Abstract
⺠GLP-2 increases transepithelial electrical resistance in this Caco-2 model of the intestinal epithelium. ⺠Observed changes in transepithelial electrical resistance translate in increases in occludin and ZO-1 protein expression. ⺠GLP-2 attenuates TNFα-induced reduction in transepithelial electrical resistance and tight junction protein expression.
Keywords
IGFtumour growth factorMLCKTNBSTNFRIFNγGLP-2TEERTGFTNFαDSSVIPNFκBMAGUKtight junctionsEDTAEthylenediaminetetraacetic acidSDS-PAGEsodium dodecyl sulphate polyacrylamide gel electrophoresisinterleukinCrohn's diseaseInflammatory bowel diseasetumour necrosis factor alphamyosin light chain kinasedextran sodium sulphatemembrane associated guanylate kinaseInsulin growth factornuclear factor κBTransepithelial resistanceIntestinal permeabilityTight junction proteinsUlcerative colitisInterferon gammatumour necrosis factor receptor
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Authors
G.W. Moran, C. O'Neill, J.T. McLaughlin,