| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8361382 | Regulatory Peptides | 2012 | 6 Pages |
Abstract
⺠DP4 is a serine type protease that cleaves enteroendocrine peptides GLP-1, GLP-2, PYY and GIP. ⺠The role of DP4 has not been explored in gut inflammation. ⺠Decreased tissue and plasma DP4 expression was demonstrated in Crohn's disease. ⺠This may impact on the activity of EEC derived regulatory peptides. ⺠DP4 is a potential therapeutic target in inflammatory bowel disease.
Keywords
TMBDP4succinate dehydrogenase complex, subunit Aenteroendocrinepolypeptide YYCDAIsdhAHSKPYYEECGIPLNAIBDHRPTBSGAPDHPVDFRT qPCRDSS3,3′,5,5′-tetramethylbenzidineRheumatoid arthritisIntestinal inflammationCrohn's diseaseInflammatory bowel diseaseanalysis of varianceANOVATris buffered salineHouse-keeping genedipeptidyl peptidase 4real time quantitative polymerase chain reactionEnteroendocrine celldextran sodium sulphateCrohn's Disease Activity IndexSystemic lupus erythematosusSLEwild typeHorseradish peroxidaseC-reactive proteinCRPPolyvinylidene fluorideUlcerative colitisglyceraldehyde 3 phosphate dehydrogenaseglucose-dependent insulinotropic polypeptide
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Authors
G.W. Moran, C. O'Neill, P. Padfield, J.T. McLaughlin,