| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8361392 | Regulatory Peptides | 2012 | 9 Pages |
Abstract
⺠We tested if XNT, an ACE2 activator, would improve diabetes-induced heart dysfunction. ⺠Diabetic rats showed heart dysfunction/hypertrophy/fibrosis which were blunted by XNT. ⺠ACE2 activation also increased cardiac ACE2/ACE ratio and decreased AT1 expression. ⺠Inhibition of ERK and modulation of AMPK-α and β1 are also involved in these effects. ⺠Activation of intrinsic ACE2 protects the heart against diabetes-induced dysfunction.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Tatiane M. Murça, PatrÃcia L. Moraes, Carolina A.B. Capuruço, Sérgio H.S. Santos, Marcos B. Melo, Robson A.S. Santos, Vinayak Shenoy, Michael J. Katovich, Mohan K. Raizada, Anderson J. Ferreira,