| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8361456 | Regulatory Peptides | 2012 | 7 Pages |
Abstract
⺠Endoplasmic Reticulum (ER) stress is induced by high glucose in human umbilical vein endothelial cells (HUVECs). ⺠GLP-1 analogue liraglutide prevented the onset of ER stress in HUVECs exposed to high glucose. ⺠Liraglutide may exert its effects by inducing mitochondrial fusion via OPA1 activation.
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Authors
Bruno Schisano, Alison L. Harte, Konstantinos Lois, Ponnusamy Saravanan, Nasser Al-Daghri, Omar Al-Attas, Lotte B. Knudsen, Philip G. McTernan, Antonio Ceriello, Gyanendra Tripathi,