| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8361492 | Regulatory Peptides | 2012 | 8 Pages |
Abstract
⺠The corticotrophin-releasing factor receptor 2β (CRFR2β) is expressed in the myocardium. ⺠The cardioprotective effects of CRF treatment were mediated by CRFR2 via PKA and PKC signaling downstream of CRFR2. ⺠This cardioprotection was independent of mitogen activated protein kinase-ERK1/2 signaling.
Keywords
ACTHEBDEpacPD98059CRFR2PKCLVDPUCNpKaCRFEC50TTCDulbecco's modified Eagle's minimal essential mediumDMEMCRFRrisk zonePBSH-89HEPESnuclear magnetic resonance3′-5′-cyclic adenosine monophosphate4-(2-hydroxyethyl)-1-piperazineethanesulfonic acidcAMPDNAdeoxyribonucleic acidUrocortinIschemiaSimulated ischemiaRegional ischemialeft ventricleanalysis of varianceANOVATriphenyltetrazolium chlorideEnzyme-linked immunosorbent assayELISANMRcoronary flowCardioprotectionApoptosisEvans Blue dyecorticotrophin releasing factorPhosphate buffered salineadrenocorticotropic hormoneExchange protein directly activated by cAMPprotein kinase AProtein kinase Cmitogen activated protein kinaseextracellular signal-regulated kinases
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Anne K. Jonassen, Anita Wergeland, Erik Helgeland, Ole D. Mjøs, Bhawanjit K. Brar,