Article ID Journal Published Year Pages File Type
8361561 Regulatory Peptides 2011 7 Pages PDF
Abstract
► Apelin at dose 20ug/kg increased +LVdp/dt max and -LV dp/dt max of the heart. ► Apelin at dose 40ug/kg strongly decreased SBP, DBP, and the above two indices. ► 2K1C did not change apelin, aldosterone and AVP levels but increased angII level. ► 2K1C decreased apelin receptor mRNA and protein expression in non- cliped kidney. ► Apelin with RAS antagonism may be useful therapeutic goals in 2K1C hypertension.
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