| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8361633 | Regulatory Peptides | 2011 | 8 Pages |
Abstract
⺠We study the role of aldosterone in HSC contraction and the underlying mechanisms. ⺠We use primary HSCs to examine aldosterone-induced changes in actin fiber formation and protein expressions in the RhoA/ROCK-2/P-MLC cascade. ⺠Aldosterone induces contraction of activated HSCs through the activation of the RhoA/ROCK-2 signaling pathway. ⺠This finding may provide a potential therapeutic target for control of cirrhosis and portal hypertension.
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Authors
Hongli Ji, Ying Meng, Xiaolan Zhang, Wei Luo, Pingsheng Wu, Bing Xiao, Zhenshu Zhang, Xu Li,