A 4-arm polyethylene glycol derivative conjugated with exendin-4 peptide and palmitylamine having dual-function of size-increase and albumin-binding for long hypoglycemic action

► We prepared and evaluated a 4-arm PEG conjugated with exendin-4 and palmitylamine. ► This conjugate displayed the improved pharmacokinetics and hypoglycemic efficacy. ► Such improvements were due to its increased size and HSA-binding ability. ► We consider that this exendin-4 derivative has a potential for treating diabetes.