Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8361755 | Seminars in Cancer Biology | 2018 | 14 Pages |
Abstract
The Forkhead box O (FoxO) proteins comprise a family of evolutionarily conserved transcription factors that predominantly function as tumor suppressors. These proteins assume diverse roles in the cellular anti-neoplastic response, including regulation of apoptosis and autophagy, cancer metabolism, cell-cycle arrest, oxidative stress and the DNA damage response. More recently, FoxO proteins have been implicated in cancer immunity and cancer stem-cell (CSC) homeostasis. Interestingly, in some sporadic sub-populations, FoxO protein function may also be manipulated by factors such as β-catenin whereby they instead can facilitate cancer progression via maintenance of CSC properties or promoting drug resistance or metastasis and invasion. This review highlights the essential biological functions of FoxOs and explores the areas that may be exploited in FoxO protein signaling pathways in the development of novel cancer therapeutic agents.
Keywords
PGC1αGLUT1ERαG6PCSIRTmTORCIKKCMLChlTKIHDACERKTGFβHIF1αleukemia-initiating cellNTCJnkLIChypoxia-inducible factor 1 αHSCc-Jun NH2-terminal kinaseCSCataxia telangiectasia mutatedHDACisROStransforming growth factor-βforkhead Box OATMCancer therapyTumor suppressorRegulatory T cellTreg cellHematopoietic stem cellNatural killer cellcancer stem cellAnti-neoplasticFoxOphosphoenolpyruvate carboxykinaseClassical Hodgkin lymphomachronic myelogenous leukemiaHDAC inhibitorsImmunityTyrosine kinase inhibitorMammalian target of rapamycin complexhistone deacetylasePtenglucose transporter 1glucose-6-phosphataseReactive oxygen species
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Authors
Tianyun Hou, Zhiming Li, Ying Zhao, Wei-Guo Zhu,