Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8361830 | Seminars in Cancer Biology | 2017 | 66 Pages |
Abstract
Mitochondria play fundamental roles in the regulation of life and death of eukaryotic cells. They mediate aerobic energy conversion through the oxidative phosphorylation (OXPHOS) system, and harbor and control the intrinsic pathway of apoptosis. As a descendant of a bacterial endosymbiont, mitochondria retain a vestige of their original genome (mtDNA), and its corresponding full gene expression machinery. Proteins encoded in the mtDNA, all components of the multimeric OXPHOS enzymes, are synthesized in specialized mitochondrial ribosomes (mitoribosomes). Mitoribosomes are therefore essential in the regulation of cellular respiration. Additionally, an increasing body of literature has been reporting an alternative role for several mitochondrial ribosomal proteins as apoptosis-inducing factors. No surprisingly, the expression of genes encoding for mitoribosomal proteins, mitoribosome assembly factors and mitochondrial translation factors is modified in numerous cancers, a trait that has been linked to tumorigenesis and metastasis. In this article, we will review the current knowledge regarding the dual function of mitoribosome components in protein synthesis and apoptosis and their association with cancer susceptibility and development. We will also highlight recent developments in targeting mitochondrial ribosomes for the treatment of cancer.
Keywords
Pentatricopeptide repeat proteinOXPHOSMTERFEF-TsPOLRMTBcl-2LSUSSUtranscription factor A, mitochondrialIFN-γFASTKD2PPRtRNADAP3FADDmitochondrial RNA polymeraseDrp1LETM1TFAMPKBNRF1IPS-1Mct1mRNALCKTNFαBcl-2 homologous antagonist killerMRPsJnkAMLGTPrRNASMACHDM2AIPCEF-GNrf2TCAPGC1-αfMet-tRNAc-Jun N-terminal kinasesMitochondrial DNAEF-TuMAPKmitochondrial outer membrane permeabilizationmessenger RNARibosomal RNAROStransfer RNAinterferon-gammaBaxtumor necrosis factor alphaDEAD boxApoptosisTherapySecond mitochondria-derived activator of caspasemtDNAMitochondrial ribosomesCancerAndrogen-independent prostate cancercAMP signalingElongation factor GInitiation factor 3Nuclear respiratory factor 1nuclear respiratory factor 2Fas LigandFasLMitochondrial transcription termination factorOxidative phosphorylationTRAILB-cell lymphoma 2acute myeloid leukemiatumor necrosis factor-related apoptosis-inducing ligandMOMPGenome-wide association studiesGWASmonocarboxylate transporter 1large subunitsmall subunitBcl-2-associated X proteinlymphocyte-specific protein tyrosine kinaseFas-associated protein with death domaindynamin-related protein 1protein kinase BBAKSingle nucleotide polymorphismtricarboxylic acid cycleSNPHead and neck squamous cell carcinomamitogen-activated protein kinasesGuanosine triphosphateReactive oxygen species
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Hyun-Jung Kim, Priyanka Maiti, Antoni Barrientos,