Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8361849 | Seminars in Cancer Biology | 2017 | 40 Pages |
Abstract
Mitochondria are essential intracellular organelles that regulate energy metabolism, cell death, and signaling pathways that are important for cell proliferation and differentiation. Therefore, mitochondria are fundamentally implicated in cancer biology, including initiation, growth, metastasis, relapse, and acquired drug resistance. Based on these implications, mitochondria have been proposed as a major therapeutic target for cancer treatment. In addition to classical view of mitochondria in cancer biology, recent studies found novel pathophysiological roles of mitochondria in cancer. In this review, we introduce recent concepts of mitochondrial roles in cancer biology including mitochondrial DNA mutation and epigenetic modulation, energy metabolism reprogramming, mitochondrial channels, involvement in metastasis and drug resistance, and cancer stem cells. We also discuss the role of mitochondria in emerging cancer therapeutic strategies, especially cancer immunotherapy and CRISPR-Cas9 system gene therapy.
Keywords
CypDANTMPTPHIF-1αVDACmitoKATPIDHCyclophilin DPrx3ND5PGC1-αCSCLAG-3CLIC4Mitochondrial ATP-sensitive potassium channelTASK-3CTLA-4CRISPR–Cas9peroxisome proliferator-activated receptor gamma, coactivator 1 alpha∆ψmNADH dehydrogenase 5SAMSDHGSHMCUTCATNBCPD-1Nrf2PDCCRISPR-Cas9keap1Mitochondrial DNAROS/RNSS-adenosyl-L-methioninecytotoxic T lymphocyte antigen 4mitochondrial permeability transition poreIsocitrate dehydrogenaseCancer immunotherapyadenine nucleotide translocatorTim-3Uncoupling proteinsmtDNATriple-negative breast cancercancer stem cellsuccinate dehydrogenasefumarate hydrataseProgrammed death-1MACMitochondriaETcMitochondrial inner membrane potentialperoxiredoxin 3Kelch-like ECH-associated protein 1pyruvate dehydrogenase complextricarboxylic acid cycleLymphocyte activation gene 3voltage dependent anion channelGlutathione
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Authors
Hyoung Kyu Kim, Yeon Hee Noh, Bernd Nilius, Kyung Soo Ko, Byoung Doo Rhee, Nari Kim, Jin Han,