Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8366735 | Steroids | 2016 | 29 Pages |
Abstract
There is still little evidence about BPA regulation of ion channel expression and function. However, this information is key to understand how BPA disrupts excitable and non-excitable cells, including neurons, endocrine cells and muscle cells. This report is the result of a comprehensive literature review on the effects of BPA on ion channels. We conclude that there is evidence to say that these important molecules may be key end-points for EDCs acting as xenoestrogens. However, more research on channel-mediated BPA effects is needed. Particularly, mechanistic studies to unravel the pathophysiological actions of BPA on ion channels at environmentally relevant doses.
Keywords
NMDAICRACOrai1RyRCFTRα-amino-3-hydroxyl-5-methyl-4-isoxazole-propionateN-methyl-d-aspartateBPATTXTBBPAAMPATrpHEK17β-estradiolEDCsPancreatic β-cellsBisphenol Atetrodotoxincystic fibrosis transmembrane conductance regulatorhuman embryonic kidney cellsendocrine disruptorEndocrine-disrupting chemicalstransient receptor potentialIon channelGABAAEstrogen receptorRyanodine receptors
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Authors
Sergi Soriano, Cristina Ripoll, Paloma Alonso-Magdalena, Esther Fuentes, Ivan Quesada, Angel Nadal, Juan Martinez-Pinna,