Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8366950 | Steroids | 2013 | 8 Pages |
Abstract
- Vulvar and vaginal atrophy (VVA) affects up to about 50% of postmenopausal women.
- Ospemifene is an estrogen receptor agonist/antagonist with tissue-specific effects.
- Ospemifene has beneficial estrogen-like effects on the vaginal epithelium.
- Effects are neutral on endometrium, antiestrogenic on breast, and estrogenic on bone.
- The preclinical findings are consistent with clinical studies for treatment of VVA.
Keywords
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Authors
Lauri Kangas, Mikko Unkila,