Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8401925 | Advanced Drug Delivery Reviews | 2018 | 65 Pages |
Abstract
Extracellular matrix (ECM) is a dynamic network of macromolecules, playing a regulatory role in cell functions, tissue regeneration and remodeling. Wound healing is a tissue repair process necessary for the maintenance of the functionality of tissues and organs. This highly orchestrated process is divided into four temporally overlapping phases, including hemostasis, inflammation, proliferation and tissue remodeling. The dynamic interplay between ECM and resident cells exerts its critical role in many aspects of wound healing, including cell proliferation, migration, differentiation, survival, matrix degradation and biosynthesis. Several epigenetic regulatory factors, such as the endogenous non-coding microRNAs (miRNAs), are the drivers of the wound healing response. microRNAs have pivotal roles in regulating ECM composition during wound healing and dermal regeneration. Their expression is associated with the distinct phases of wound healing and they serve as target biomarkers and targets for systematic regulation of wound repair. In this article we critically present the importance of epigenetics with particular emphasis on miRNAs regulating ECM components (i.e. glycoproteins, proteoglycans and matrix proteases) that are key players in wound healing. The clinical relevance of miRNA targeting as well as the delivery strategies designed for clinical applications are also presented and discussed.
Keywords
ECMADAMTSuPAHSPGHASPDGFαSMAncRNAsGAGMIRCTGFpri-miRNAFGFprimary microRNAtPANdst1NF-κBMMPSLRPsEGFTGF-βHPSEADAMs with thrombospondin motifsADAMsnon-coding RNAsTLRsalpha smooth muscle actinWound HealinginterleukinTransforming growth factor βa disintegrin and metalloproteinasestumor necrosis factor αEMTRISCTIMPKeratan sulfateDermatan sulfateepidermal growth factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Connective tissue growth factorplatelet-derived growth factorfibroblast growth factorTNF-αnuclear factor-κBTissue-type plasminogen activatorurokinase-type plasminogen activatorFibrosisLAMLamininExtracellular matrixMetalloproteinaseRNA-Induced Silencing ComplexUTR یا untranslated regions untranslated regionTissue inhibitor of metalloproteinaseMicroRNAPharmacological targetingHeparan sulfateHeparanaseHeparan sulfate proteoglycanHyaluronanHyaluronan synthaseProteoglycanCollagenChondroitin sulfatecolepithelial-to-mesenchymal transitionGlycosaminoglycanToll-like receptors
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Authors
Zoi Piperigkou, Martin Götte, Achilleas D. Theocharis, Nikos K. Karamanos,