Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8485328 | Tuberculosis | 2016 | 11 Pages |
Abstract
Understanding the immunomodulatory properties of these cell wall glycolipids, how they differ between distinct Mtb strains, and how they influence the degree of Mtb virulence, is of utmost relevance to understand how the host mounts a protective or otherwise pathologic immune response. This is essential for the design of preventive strategies against tuberculosis. Thus, since clarifying the controversy on this matter is crucial we here review, summarize and discuss reported data from in vitro stimulation with the three major Mtb complex cell wall glycolipids (ManLAM, PIMs and LM) in an attempt to conciliate the conflicting findings.
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Authors
Gunilla Källenius, Margarida Correia-Neves, Helen Buteme, Beston Hamasur, Stefan B. Svenson,