Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8485339 | Tuberculosis | 2016 | 8 Pages |
Abstract
Co-administration of clofazimine, thioridazine, timcodar, SQ109 and possibly rifampicin with drugs that are substrates for the inhibited transporters may lead to DDIs. The mycobacterial EPIs potently inhibited a wider range of human ABC transporters than previously reported. These vesicular transport data are especially valuable considering the current emphasis on development of TB drug regimens.
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Authors
Lindsey H.M. te Brake, Frans G.M. Russel, Jeroen J.M.W. van den Heuvel, Gerjo J. de Knegt, Jurriaan E. de Steenwinkel, David M. Burger, Rob E. Aarnoutse, Jan B. Koenderink,