Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8507667 | Acta Pharmaceutica Sinica B | 2018 | 11 Pages |
Abstract
Downstream ERK kinase appears to be the Achilles' Heel of the MAPK pathway. Targeting ERK kinase provides potential therapeutic opportunities for a broad spectrum of cancers bearing RAS, RAF and MEK mutations as well as those with acquired resistance to BRAF and MEK inhibitors (RAFi and MEKi).109
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Authors
Feifei Liu, Xiaotong Yang, Meiyu Geng, Min Huang,