| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8507672 | Acta Pharmaceutica Sinica B | 2018 | 12 Pages |
Abstract
Garlic-derived S-allylmercaptocysteine (SAMC) directly interacts with cancer cell membrane-bound receptor low-density lipoprotein receptor-related protein 6 (LRP6) to modulate the activation of the Wnt/β-catenin pathway. The apoptosis of cancer cell is promoted through the c-Myc- and Mcl-1-mediated pathways, while the proliferation of cancer cell is inhibited via the converged PCNA/p53/p21 regulations.224
Keywords
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Authors
Jia Xiao, Feiyue Xing, Yingxia Liu, Yi Lv, Xiaogang Wang, Ming-Tat Ling, Hao Gao, Songying Ouyang, Min Yang, Jiang Zhu, Yu Xia, Kwok-Fai So, George L. Tipoe,