| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8507682 | Acta Pharmaceutica Sinica B | 2018 | 10 Pages |
Abstract
Twenty-six new tricyclic matrinic derivatives were designed, synthesized and evaluated for their activities against Ebola virus in vitro using a pHIV-EBOVGP-Fluc model. Compound 7d exhibited better in vivo anti-EBOV and anti-MARV effects than the positive control sertraline. The results suggested its inspiring broad-spectrum anti-filovirus activity.237
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Authors
Xin Zhang, Qiang Liu, Qianqian Li, Yinghong Li, Zhandong Liu, Hongbin Deng, Sheng Tang, Yanxiang Wang, Youchun Wang, Danqing Song,