Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8507776 | Acta Pharmaceutica Sinica B | 2018 | 35 Pages |
Abstract
Eight new C19-diterpenoid alkaloid arabinosides, named aconicarmichosides EâL (1â8), were isolated and characterized from an aqueous extract of the lateral roots of Aconitum carmichaelii (Fu Zi). These compounds, together with the previously reported four neoline 14-O-arabinosides from the same extract, represent the only examples of glycosidic diterpenoid alkaloids from nature. At a dose of 1.0 mg/kg (i.p.), compounds 1, 2, and 4-6 exhibited analgesic effects against acetic acid-induced writhing of mice.320
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Authors
Qinglan Guo, Huan Xia, Xianhua Meng, Gaona Shi, Chengbo Xu, Chenggen Zhu, Tiantai Zhang, Jiangong Shi,