Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8507808 | Acta Pharmaceutica Sinica B | 2018 | 10 Pages |
Abstract
Genome mining revealed an unconventional paraherquonin-like meroterpenoid biosynthetic gene cluster in the chromosome of Neosartorya glabra. Overexpression of the pathway specific transcriptional regulator (BerA) led to the production of two new compounds berkeleyacetal D (1) and 11-epi-berkeleyacetal C (2). The biosynthetic pathway of berkeleyacetals was proposed by a combined approach, comprising molecular biology, bioinformatics and chemical analysis.185
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Authors
Tao Zhang, Jun Wan, Zhajun Zhan, Jian Bai, Bingyu Liu, Youcai Hu,