| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8507826 | Acta Pharmaceutica Sinica B | 2018 | 12 Pages |
Abstract
The present study exhibited a highly significant effect (P<0.005) on NAT2 activity in peripheral blood mononuclear cells once deacetylation function of sirtuins is inhibited by nicotinamide (NAM) generating high levels of Ac-INH which suggests a post-translational regulatory mechanism.170
Keywords
PBSRSVSirtuinsPGC-1αsirtuinSIRTE2F1APCRUNX3SREBP2NATFOXO1SMZPGAM1FITCINHPBMCER81peroxisome proliferator-activated receptor-gamma coactivator 1αDMEMDulbecco's modified Eagle's mediumP-aminobenzoic acidarylamine N-acetyltransferaseallophycocyaninisoniazidChoResveratrolChinese hamster ovary cellsperipheral blood mononuclear cellsSulfamethazineRunt-related transcription factor 3Phosphoglycerate mutase 1Phosphate-buffered salineNADNAMPASnicotinamide adenine dinucleotideNicotinamidePABAForkhead box protein O1sterol regulatory element-binding protein 2Helahigh performance liquid chromatographyHPLC
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Authors
Eneida Turiján-Espinoza, Rául Alejandro Salazar-González, Edith Elena Uresti-Rivera, Gloria Estela Hernández-Hernández, Montserrat Ortega-Juárez, Rosa Milán, Diana Portales-Pérez,