| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8507830 | Acta Pharmaceutica Sinica B | 2018 | 9 Pages |
Abstract
We established a pseudo-filovirus-based sequential in vitro and in vivo filovirus entry inhibitor evaluation system that can be performed in BSL-2 facilities. The system covers all filovirus genera, including three bioluminescence imaging in vivo mouse models. The success of model establishments was confirmed by two known filovirus entry inhibitors.184
Keywords
CLOd.p.i.the 50% inhibitory concentrationSudan virusBundibugyo virusEBOVDLITVSV-GRAVVLloviu virusTORei.p.ROIBSLh.p.i.IC503-dimensionalFilovirusPseudovirusEbolastandard deviationstandard error of the meanIntraperitoneallyday post-infectionhour post-infectionbiosafety levelLogarithmMarburgMARVSEMMouse modelregion of interestEntry inhibitorEbola virusMarburg virusClomipheneGlycoproteinvesicular stomatitis virus glycoprotein
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Authors
Qing Chen, Ke Tang, Xiaoyu Zhang, Panpan Chen, Ying Guo,