| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8508007 | Acta Pharmaceutica Sinica B | 2017 | 8 Pages |
Abstract
The inhibitory potentials of icotinib and erlotinib against UDP-glucuronosyltransferase 1A1 (UGT1A1) were investigated and compared for the first time. Icotinib exhibited relatively weak inhibition against UGT1A1 in human liver microsomes compared to erlotinib. In addition, icotinib was unlikely to cause a significant drug-drug interaction (DDI) through inhibition of UGT1A1, while erlotinib exhibited much higher DDI potentials.147
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Authors
Xuewei Cheng, Xia Lv, Hengyan Qu, Dandan Li, Mengmeng Hu, Wenzhi Guo, Guangbo Ge, Ruihua Dong,