Identification of the primary determining factor(s) governing the oral absorption of edaravone in rats

Article ID	Journal	Published Year	Pages	File Type
8510659	European Journal of Pharmaceutical Sciences	2018	9 Pages	PDF

Keywords

basolateral to apical FDA MDCKII P-gp CMC MDR1 AUC DMSO LC-MS/MS P-glycoprotein t1/2 VSs Edaravone Sprague-Dawley analysis of variance ANOVA clearance Oral absorption volume of distribution at steady state Intravenous per oral Dimethyl sulfoxide Food and Drug Administration Sodium vanadate Liquid chromatography-mass spectrometry Pharmacokinetics Bioavailability area under the curve Extraction ratio Apparent permeability Half-life Papp multidrug resistance protein 1 Carboxymethyl cellulose Madin-Darby canine kidney Permeability glycoprotein

Related Topics

Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Drug Discovery

Identification of the primary determining factor(s) governing the oral absorption of edaravone in rats

Authors

Sungwoo Hyung, Yoo-Seong Jeong, Jungmin Yeo, Yoo-Kyung Song, Min-Soo Kim, Young-Jae Im, Han-Joo Maeng, Suk-Jae Chung,