In vitro assessment of the interactions of dopamine Î²-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein

Article ID	Journal	Published Year	Pages	File Type
8511335	European Journal of Pharmaceutical Sciences	2018	6 Pages	PDF

Keywords

DBH HBSS DAD Bcrp TEER EMA MDCK P-gp [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide]DDIs BSA DMSO Hanks balanced salt solution MTT P-glycoprotein bovine serum albumin European Medicines agency standard deviation Diode-array detection drug-drug interactions dopamine β-hydroxylase dopamine beta-hydroxylase Dimethyl sulfoxide BBB Hypertension Sodium fluorescein Blood-brain barrier transepithelial electrical resistance Apparent permeability Papp breast cancer resistance protein high performance liquid chromatography HPLC Madin-Darby canine kidney

Related Topics

Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Drug Discovery

In vitro assessment of the interactions of dopamine Î²-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein

Authors

Joana Bicker, Gilberto Alves, Ana Fortuna, PatrÃcio Soares-da-Silva, AmÃlcar FalcÃ£o,