Role of efflux transporters in the absorption, distribution and elimination in rodents of a novel PDE4 inhibitor, CHF6001

Article ID	Journal	Published Year	Pages	File Type
8511596	European Journal of Pharmaceutical Sciences	2018	52 Pages	PDF

Keywords

Cmax phosphodiesterase-4 inhibitor QWBA AUCinf PSL MDR1 IVC Bcrp tmax cGMP ADME CMC BDC NCI LSC LLOQ cAMP t1/2 VSs Oral administration standard deviation Becquerel Chronic obstructive pulmonary disease COPD clearance Intravenous administration absorption, distribution, metabolism and excretion Rodents volume of distribution at steady state Membrane transporters Radiolabelled BBB liquid scintillation counting maximal concentration Pharmacokinetics Photo-stimulated luminescence Blood-brain barrier lower limit of quantitation PDE4 inhibitors knockout Half-life time Inferior vena cava breast cancer resistance protein polyethylene glycol PEG carboxymethylcellulose

Related Topics

Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Drug Discovery

Role of efflux transporters in the absorption, distribution and elimination in rodents of a novel PDE4 inhibitor, CHF6001

Authors

V. Cenacchi, M. Salvadori, B. Riccardi, G. Brogin, A. Ghiglieri, M. Messina, G. Imre, P. Puccini,