Prediction of human pharmacokinetics of activated recombinant factor VII and B-domain truncated factor VIII from animal population pharmacokinetic models of haemophilia

Article ID	Journal	Published Year	Pages	File Type
8511638	European Journal of Pharmaceutical Sciences	2018	31 Pages	PDF

Keywords

GOF rFVIIa RSE Activated recombinant factor VII Recombinant factor VIII rFVIII relative standard error IIV goodness-of-fit Interspecies Inter-individual variability Coagulation factors pharmacokinetic Pharmacokinetic modelling Allometric scaling Prediction

Related Topics

Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Drug Discovery

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Prediction of human pharmacokinetics of activated recombinant factor VII and B-domain truncated factor VIII from animal population pharmacokinetic models of haemophilia

Authors

Malte Selch Larsen, Rasmus Vestergaard Juul, Andreas Velsing Groth, Ulrika S.H. Simonsson, Annemarie T. Kristensen, Tom Knudsen, Henrik AgersÃ¸, Mads Kreilgaard,