| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8512034 | European Journal of Pharmaceutical Sciences | 2018 | 62 Pages |
Keywords
CyPDDITPMPBPKVmaxPHTCSSUGTHLMLEVCLRCminFBMLTGCbzPRMVPAExtended-releaseOXCAEDCmaxB/PRFNAUCt1/2UDP-glucuronosyltransferaseADAMstandard deviationOxcarbazepineParameter estimationclearancedrug-drug interactionFraction unboundTopiramateAbsorption rate constantVolume of distributionMichaelis-Menten constantIntravenousantiepileptic drugantiepileptic drugstwice dailyRufinamideTIDthree times dailyCytochrome P450body mass indexBMIMass spectrometryPeak plasma concentrationpharmacokineticPhysiologically based pharmacokineticFraction absorbedFelbamatePhenobarbitalPhenytoinImmediate-releaseLamotriginelevetiracetamlorazepamPhysiologically based pharmacokinetic modelinhibition constanthuman liver microsomeArea-under-the-curvehalf lifeValproic acidIntrinsic clearanceprimidoneBIDcarbamazepineliquid chromatographyClintrenal clearanceonce daily
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
Todd M. Conner, Vahagn C. Nikolian, Patrick E. Georgoff, Manjunath P. Pai, Hasan B. Alam, Duxin Sun, Ronald C. Reed, Tao Zhang,