IMI - oral biopharmaceutics tools project - evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

Article ID	Journal	Published Year	Pages	File Type
8512516	European Journal of Pharmaceutical Sciences	2017	45 Pages	PDF

Keywords

FUP logarithm of the octanol/water partition coefficient Cmax tmax Frel IMI API DDI PBPK logP EFPIA AUC innovative medicines initiative Biopharmaceutics Absolute oral bioavailability clearance drug-drug interaction Absorption Volume of distribution maximum concentration M&S BCs time at maximum concentration biopharmaceutics classification system Pharmacokinetics physiologically-based pharmacokinetic relative bioavailability Modelling and simulation area under the curve Active Pharmaceutical Ingredient blood-to-plasma ratio Effective permeability Molecular weight Drug database Peff fraction unbound in plasma

Related Topics

Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Drug Discovery

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IMI - oral biopharmaceutics tools project - evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

Authors

Alison Margolskee, Adam S. Darwich, Xavier Pepin, Shriram M. Pathak, Michael B. Bolger, Leon Aarons, Amin Rostami-Hodjegan, Jonas Angstenberger, Franziska Graf, Loic Laplanche, Thomas Müller, Sara Carlert, Pankaj Daga, Dónal Murphy,