| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8513259 | Journal of Pharmaceutical Sciences | 2018 | 29 Pages |
Abstract
A cocrystal of glibenclamide, an antidiabetic drug classified as type II compound according to the Biopharmaceutics Classification System, has been synthesized using tromethamine as coformer in 1:1 molar ratio, by slow solvent evaporation cocrystalization. The cocrystal obtained was characterized by X-ray powder diffraction, differential scanning calorimetry, Raman, mid infrared, and near-infrared spectroscopy. The results consistently show the formation of a cocrystal between active pharmaceutical ingredients and conformer with the synthons corresponding to hydrogen bonding between hydrogen in amines of tromethamine and carbonyl and sulfonyl groups in glibenclamide.
Keywords
Related Topics
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Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
Silvério Ferreira Silva Filho, Andreia Cardoso Pereira, Jorge M.G. Sarraguça, Mafalda C. Sarraguça, João Lopes, Pedro de Freitas Façanha Filho, Adenilson Oliveira dos Santos, Paulo Roberto da Silva Ribeiro,