Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8513483 | Journal of Pharmaceutical Sciences | 2018 | 34 Pages |
Abstract
A new monohydrated polymorph of dexamethasone acetate was crystallized and its crystal structure characterized. The different analytical techniques used for describing its structural and vibrational properties were: single crystal and polycrystal X-ray diffraction, solid state nuclear magnetic resonance, infrared spectroscopy. A Hirshfeld surface analysis was carried out through self-arrangement cemented by H-bonds observed in this new polymorph. This new polymorph form appeared because of self-arrangement via classical hydrogen bonds around the water molecule.
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Authors
Ronaldo Pedro da Silva, Mateus Felipe Schuchter Ambrósio, Luciana Almeida Piovesan, Maria Clara Ramalho Freitas, Daniel Lima Marques de Aguiar, Bruno Araújo Cautiero Horta, Eugenio Kahn Epprecht, Rosane Aguiar da Silva San Gil,