| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8513845 | Journal of Pharmaceutical Sciences | 2017 | 16 Pages |
Abstract
Physiologically based pharmacokinetic modeling is a commonly used strategy in the drug development and regulatory submissions. This commentary provides a critical overview of the current status of physiologically based pharmacokinetic methodologies to predict transporter-mediated pharmacokinetics, in addition to the impact of disease and genetics with respect to local and systemic concentration.
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Authors
Aleksandra Galetin, Ping Zhao, Shiew-Mei Huang,