Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8513946 | Journal of Pharmaceutical Sciences | 2017 | 37 Pages |
Abstract
Punch sticking is a complex phenomenon influenced primarily by particle size, tooling surface roughness, tooling design, and tooling construction material. When particle and environmental factors are controlled, compaction pressure has a distinct effect on punch sticking behavior for a given active pharmaceutical ingredient (API). This research focuses on the effect of compaction pressure on punch sticking using 5 compounds with different sticking propensities. The results collectively show that sticking tends to be more problematic under higher compaction pressures and for more ductile compounds. This is attributed to the greater punch surface coverage by the API and the stronger cohesion of API to the existing API layer on the punch.
Keywords
Related Topics
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Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
Shubhajit Paul, Kunlin Wang, Lisa J. Taylor, Brendan Murphy, Joseph Krzyzaniak, Neil Dawson, Matthew P. Mullarney, Paul Meenan, Changquan Calvin Sun,