| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8514826 | Journal of Pharmaceutical Sciences | 2016 | 8 Pages |
Abstract
A new polymorphic form of otilonium bromide is presented (Form I), and a thorough analysis of its crystal and molecular structure is performed. The compound suffers a temperature-driven first-order phase transition at about 396 K, which transforms it into the polymorph reported by Dapporto P and Sega A (Acta Cryst. 1986;C42:474-478) (Form II). Through thermal analysis and solubility experiments the relative stability of both crystal modifications were determined, confirming that at room temperature this new Form I is the more stable one, Form II existing just in a metastable state.
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Authors
Daniel R. Vega, Emilia Halac, Luciano Segovia, Ricardo Baggio,