Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8518992 | Asian Journal of Pharmaceutical Sciences | 2018 | 23 Pages |
Abstract
Endotoxin can be measured mainly by two methods: the Rabbit Pyrogen Test (RPT) and Limulus Amebocyte Lysate (LAL) assay. We found that a chemotherapeutic drug nanoformulation composed of irinotecan hydrochloride and an amphiphilic molecule DSPE-mPEG2000 can interfere with the LAL. Furthermore, the RPT results indicated that at a relatively high dosage, the drug irinotecan hydrochloride can induce a hypothermia effect which forces us to reduce the dose. So it is necessary to develop new methods for the detection of endotoxin.
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Authors
Yanan Jin, Juanjuan Jia, Chan Li, Jianqi Xue, Jiabei Sun, Kaiyuan Wang, Yaling Gan, Jing Xu, Yaqin Shi, Xingjie Liang,