Article ID Journal Published Year Pages File Type
8518992 Asian Journal of Pharmaceutical Sciences 2018 23 Pages PDF
Abstract
Endotoxin can be measured mainly by two methods: the Rabbit Pyrogen Test (RPT) and Limulus Amebocyte Lysate (LAL) assay. We found that a chemotherapeutic drug nanoformulation composed of irinotecan hydrochloride and an amphiphilic molecule DSPE-mPEG2000 can interfere with the LAL. Furthermore, the RPT results indicated that at a relatively high dosage, the drug irinotecan hydrochloride can induce a hypothermia effect which forces us to reduce the dose. So it is necessary to develop new methods for the detection of endotoxin.
Related Topics
Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Pharmaceutical Science
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