Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8519160 | Contemporary Clinical Trials Communications | 2018 | 6 Pages |
Abstract
This paper considers combining a proof of concept (POC) study and a dose finding (DF) study where the POC and the DF share the same primary endpoint. An example based on real study conditions shows that compared to a conventional design the proposed adaptive design tests more active doses, with a smaller sample size and a shorter overall duration leading to a budget saving of 30% in study operations.
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Authors
Jiacheng Yuan, Daniel Radecki, Denise Bugarin, Till Geib, Jihao Zhou, Jeen Liu,