Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8522566 | Saudi Pharmaceutical Journal | 2018 | 8 Pages |
Abstract
The biological activities; antimicrobial, antioxidant and anticancer, of the red algae Galaxaura rugosa and Liagora hawaiiana were determined. The total ethanol, lipoidal matters, chloroform, n-butanol, aqueous extracts and powder of both algae showed and bacterial and antifungal activities. However, the chloroform extract of Galaxaura rugosa showed antibacterial activity against Klebsiella pneumoniae (24â¯mm, 0.15â¯mg/ml) higher than gentamycin (23â¯mm, 0.49â¯mg/ml). Moreover, the total ethanol, lipoidal matter and chloroform extracts showed antifungal activity (21, 22 and 25â¯mm, 1.25, 0.312 and 0.156â¯mg/ml) similar to the antibiotic Ketoconazole activity (23, 24 and 27â¯mm, 1.25, 0.312 and 0.156â¯mg/ml) against Aspergillus fumigatus, A. niger and Candida trobicalis, respectively. A good antioxidant activity (80.96%, IC50â¯=â¯27.8â¯Âµg/ml) was provided by Galaxaura rugosa. The anticancer activity results revealed that the lipoidal matters of Galaxaura rugosa and Liagora hawaiiana possessed antitumor activity (IC50â¯=â¯15â¯Â±â¯1.7 and 21.2â¯Â±â¯1.6, respectively) against lung carcinoma (A-549) better than vinblastine sulfate (IC50â¯=â¯24.6â¯Â±â¯0.7). Although, the lipoidal matters of Galaxaura rugosa and Liagora hawaiiana antitumor activity against cervical carcinoma (HeLa) and intestinal carcinoma (CACO-2) (IC50â¯=â¯10.2â¯Â±â¯0.6 and 12.2â¯Â±â¯0.6, respectively) preferable than vinblastine sulfate (IC50â¯=â¯59.7â¯Â±â¯2.1 and 30.3â¯Â±â¯1.4, respectively).
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Authors
Nouf M. Al-Enazi, Amani S. Awaad, Saleh I. Alqasoumi, Metab F. Alwethairi,