Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8522729 | Saudi Pharmaceutical Journal | 2017 | 9 Pages |
Abstract
The FSM dispersions revealed shear thinning flow type. Based on colloidal dispersions' rheological properties, five FSM concentrations were taken forward to the lyophilization step. Completely dry and elegant tablets were obtained. Texture analysis indicated highly porous structures, confirmed by SEM analysis, which explain the fast disintegration properties. All the prepared tablets disintegrated in less than 47 s. The disintegration process was prolonged by the increase in FSM content, due to the high viscosity the polymer creates in aqueous media. FSM tablets presented longer disintegration times, as compared to gelatin tablets, but also higher crushing strength. Considering the fast disintegration and the high crushing strength, FSM is a good candidate as matrix forming agent for fast disintegrating dosage forms or other freeze-dried preparations.
Keywords
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Authors
Sonia Iurian, Elena Dinte, Cristina Iuga, CÄtÄlina Bogdan, Iuliana Spiridon, Lucian Barbu-Tudoran, Andreea Bodoki, Ioan TomuÅ£Ä, Sorin E. LeucuÅ£a,