In vitro approach to elucidate the relevance of carboxylesterase 2 and N-acetyltransferase 2 to flupirtine-induced liver injury

Article ID	Journal	Published Year	Pages	File Type
8523806	Biochemical Pharmacology	2018	10 Pages	PDF

Keywords

CES2 AADAC BNPP BSO HLM HEK293 N-acetyl-l-cysteine PMSF MRM L-buthionine sulfoximine DFP NAT NAC NAT2 GFP DMSO LC–MS/MS MOI N-acetyltransferase Adenovirus arylacetamide deacetylase Liver injury acetyl coenzyme A CES HIM Dimethyl sulfoxide flupirtine phenylmethylsulfonyl fluoride lactate dehydrogenase LDH Drug metabolism Human Liver Microsomes Multiple-reaction monitoring green fluorescent protein multiplicity of infection Eserine carboxylesterase liquid chromatography–tandem mass spectrometry high-performance liquid chromatography HPLC

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In vitro approach to elucidate the relevance of carboxylesterase 2 and N-acetyltransferase 2 to flupirtine-induced liver injury

Authors

Keigo Konishi, Tatsuki Fukami, Takuo Ogiso, Miki Nakajima,