Induction of oxidative stress by long-term treatment of live HEK293 cells with therapeutic concentration of lithium is associated with down-regulation of Î´-opioid receptor amount and function

Article ID	Journal	Published Year	Pages	File Type
8523954	Biochemical Pharmacology	2018	12 Pages	PDF

Keywords

PMSF post nuclear supernatant MDA TMA-DPH DPH guanosine 5′-O-[gamma-thio]triphosphate GTPγS GPCR HEK293 DCFH-DA TBARS 4-HNE Dcf AAS nuclear magnetic resonance Lithium 1,6-diphenyl-1,3,5-hexatriene 2′,7′-dichlorofluorescein G protein-coupled receptors ROS [35S]GTPγS δ-Opioid receptor bipolar disorder NMR Oxidative stress G protein DADLE HEK293 cells human embryonic kidney 293 cells Atomic absorption spectroscopy ICP-MS inductively coupled plasma mass spectrometry phenylmethylsulfonyl fluoride malondialdehyde thiobarbituric acid reactive substances Antibody G proteins PNS High pressure liquid chromatography HPLC

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Induction of oxidative stress by long-term treatment of live HEK293 cells with therapeutic concentration of lithium is associated with down-regulation of Î´-opioid receptor amount and function

Authors

Miroslava Vosahlikova, Hana Ujcikova, Martina Hlouskova, Stanislav Musil, Lenka Roubalova, Martin Alda, Petr Svoboda,