Identification of enzymes responsible for dantrolene metabolism in the human liver: A clue to uncover the cause of liver injury

Article ID	Journal	Published Year	Pages	File Type
8524225	Biochemical Pharmacology	2018	10 Pages	PDF

Keywords

MNA N1-methylnicotinamide G-6-PDH G-6-P AOX1 11β-HSD NAD(P)H: quinone oxidoreductase 1 HLC NQO1 11β-hydroxysteroid dehydrogenase HLM MRM NAT GSH CBR AKR CyP NADPH XOR LC-MS/MS N-acetyltransferase Liver injury aldehyde oxidase aldehyde oxidase 1 aldo-keto reductase EDTA xanthine oxidoreductase Dantrolene human liver cytosol Cytochrome P450 SIM Liquid chromatography-tandem mass spectrometry Single ion monitoring Human Liver Microsomes multiple reaction monitoring nicotinamide adenine dinucleotide phosphate Single nucleotide polymorphism SNP Carbonyl reductase HPLC high-performance liquid chromatography glutathione, reduced form glucose-6-phosphate glucose-6-phosphate dehydrogenase

Related Topics

Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Pharmacology

Identification of enzymes responsible for dantrolene metabolism in the human liver: A clue to uncover the cause of liver injury

Authors

Takayuki Amano, Tatsuki Fukami, Takuo Ogiso, Daisuke Hirose, Jeffrey P. Jones, Tsuyoshi Taniguchi, Miki Nakajima,