The cycloartane triterpenoid ADCX impairs autophagic degradation through Akt overactivation and promotes apoptotic cell death in multidrug-resistant HepG2/ADM cells

Article ID	Journal	Published Year	Pages	File Type
8524468	Biochemical Pharmacology	2017	45 Pages	PDF

Keywords

IOD unc-51-like kinase 1 Verapamil (PubChem CID: 62969)Bafilomycin A1 (PubChem CID: 6436223)Rapamycin (PubChem CID: 5284616)Doxorubicin (PubChem CID: 31703)TFEB ULK1 CtsB HCQ PARP 3-MA MDC PMSF DAPI TCM ABC MMP PBS mTOR FBS DOX 3-methyladenine 4′,6-diamidino-2-phenylindole HCC MTT Acridine orange Akt Tem Baf A1 bafilomycin A1 integrated optical density Cycloartane triterpenoid Doxorubicin fetal bovine serum Autophagic flux traditional Chinese medicine Phenylmethanesulfonyl fluoride phosphate-buffered solution Monodansylcadaverine Transmission electron microscopy mammalian target of rapamycin hydroxychloroquine Mitochondrial membrane potential poly (ADP-ribose) polymerase Cathepsin B Hepatocellular carcinoma ATP-binding cassette

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The cycloartane triterpenoid ADCX impairs autophagic degradation through Akt overactivation and promotes apoptotic cell death in multidrug-resistant HepG2/ADM cells

Authors

Haiyan Sun, Maohua Huang, Nan Yao, Jianyang Hu, Yingjie Li, Liping Chen, Nan Hu, Wencai Ye, William Chi-Shing Tai, Dongmei Zhang, Sibao Chen,