Effects of dronedarone, amiodarone and their active metabolites on sequential metabolism of arachidonic acid to epoxyeicosatrienoic and dihydroxyeicosatrienoic acids

Article ID	Journal	Published Year	Pages	File Type
8524515	Biochemical Pharmacology	2017	11 Pages	PDF

Keywords

ESI [S]DCU physiologically based pharmacokinetic modelling Arachidonic acid (PubChem CID: 444899)CYP2J2 Cytochrome P450 2J2 AUDA CEET NDEA Dronedarone NYHA PBPK Vmax CAA CSS ACN IC50 TBS MRM 4-hydroxybenzophenone DHET sEH UPLC-MS/MS VSs Amiodarone Acetonitrile Arachidonic acid epoxyeicosatrienoic acid epoxyeicosatrienoic acids Polyunsaturated fatty acid PUFA New York Heart Association Tris-buffered saline EET Enzyme concentration Substrate concentration multiple reaction monitoring Soluble epoxide hydrolase Intrinsic clearance HPLC high-performance liquid chromatography Clint electrospray ionization

Related Topics

Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Pharmacology

Effects of dronedarone, amiodarone and their active metabolites on sequential metabolism of arachidonic acid to epoxyeicosatrienoic and dihydroxyeicosatrienoic acids

Authors

Aneesh Karkhanis, Nhan Dai Thien Tram, Eric Chun Yong Chan,