The Ca2+/CaMKK2 axis mediates the telbivudine induced upregulation of creatine kinase: Implications for mechanism of antiviral nucleoside analogs' side effect

Article ID	Journal	Published Year	Pages	File Type
8524537	Biochemical Pharmacology	2017	19 Pages	PDF

Keywords

CHB LPO DCFH-DA NAS ADP AMPK LDT HBeAg AZT ETV CaMKK2 adenosine 5′-monophosphate (AMP)-activated protein kinase p-AMPK Human skeletal muscle cells MDA Fluo-3/AM COX IV EGFR TDF AdV PBS DMSO Mitochondrial DNA ROS Adefovir Adenosine Triphosphate ATP adenosine diphosphate Nucleoside analogs Entecavir telbivudine Oxidative stress Tenofovir mtDNA Dimethyl sulfoxide Zidovudine SOD Superoxide dismutase cytochrome c oxidase subunit IV phosphate buffer saline LAM Lamivudine malondialdehyde estimated glomerular filtration rate Hepatitis B e antigen chronic hepatitis B HBV hepatitis B virus Lipid peroxide creatine Creatine kinase Creatine kinase (CK)Reactive oxygen species

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The Ca2+/CaMKK2 axis mediates the telbivudine induced upregulation of creatine kinase: Implications for mechanism of antiviral nucleoside analogs' side effect

Authors

Long Jianfei, Wang Min, Ma Chunlai, Chen Bicui, Zhang Jiming, Wang Bin,