Dehydroabietic acid isolated from Pinus elliottii exerts in vitro antileishmanial action by pro-oxidant effect, inducing ROS production in promastigote and downregulating Nrf2/ferritin expression in amastigote forms of Leishmania amazonensis

Article ID	Journal	Published Year	Pages	File Type
8530616	Fitoterapia	2018	9 Pages	PDF

Keywords

FSC-H Nrf2 IC50 Pinus elliottii mRNA RT-PCR AMB 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide FBS tPSA TMRE M199 VLC PBS TNF nuclear magnetic resonance DMSO H2DCFDA MTT messenger RNA ROS Amphotericin B Dehydroabietic acid Resin acid interleukin NMR standard error of mean DHA Diterpene Dimethylsulfoxide ACL fetal bovine serum Cytotoxity total iron binding capacity Nuclear factor erythroid 2–related factor 2 Inhibitory concentration of 50%tumor necrosis factor Phosphate buffered saline Phosphatidylserine Leishmanicidal activity American cutaneous leishmaniasis Methanol medium 199 SEM MeOH Nitric oxide reverse transcription polymerase chain reaction Propidium iodide optical density Vacuum liquid chromatography Reactive oxygen species

Related Topics

Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Pharmacology

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Dehydroabietic acid isolated from Pinus elliottii exerts in vitro antileishmanial action by pro-oxidant effect, inducing ROS production in promastigote and downregulating Nrf2/ferritin expression in amastigote forms of Leishmania amazonensis

Authors

Manoela Daiele Gonçalves, B.T.S. Bortoleti, Fernanda Tomiotto-Pellissier, Milena Menegazzo Miranda-Sapla, JoÃ£o Paulo Assolini, Amanda Cristina Machado Carloto, P.G.C. Carvalho, Ellen Takasse Tudisco, Alexandre Urbano, Sérgio Ricardo Ambrósio,