Shikonin upregulates the expression of drug-metabolizing enzymes and drug transporters in primary rat hepatocytes

Article ID	Journal	Published Year	Pages	File Type
8532420	Journal of Ethnopharmacology	2018	8 Pages	PDF

Keywords

P-gp OATP MRP GST UGT Nrf2 CyP ITS NF-E2-related factor NQO1 FBS AP1 AHR PXR keap1 MAPK NAD(P)H:quinone oxidoreductase 1 P-glycoprotein UDP-glucuronosyltransferases Drug-metabolizing enzymes insulin-transferrin-selenium Shikonin Drug transporters fetal bovine serum EMSA یا electrophoretic mobility shift assay Cytochrome P450 antioxidant-response element activating protein 1 CAR ARE Kelch-like ECH-associated protein 1 multidrug resistance-associated proteins Organic anion transporting polypeptide mitogen-activated protein kinases Glutathione transferase aryl hydrocarbon receptor constitutive androstane receptor Pregnane X receptor

Related Topics

Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Pharmacology

Shikonin upregulates the expression of drug-metabolizing enzymes and drug transporters in primary rat hepatocytes

Authors

Chin-Shiu Huang, Haw-Wen Chen, Tzu-Yu Lin, Ai-Hsuan Lin, Chong-Kuei Lii,